发给老马备查:
1 v5 O) m6 G$ i8 Y滴水察海(69304838) 15:23:23
/ F7 J0 b3 p% G9 y# `1 ?老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱( G+ J" S& p4 V6 A" T' e( O( {( U
吉非替尼和S-1连用的依据
: f1 X2 {4 ]! L; vGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.0 w' I* _7 q0 Q" P
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达 S3 N9 c, N: S; q4 I
这样是不是推理出,耐药后,可以用S-1和培美了?& H+ l; O8 S; }3 [4 l: {5 K
结论:
& O% m: x+ N% t7 {; H# G如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |