发给老马备查:
$ c6 V% h! w% o" N) R: f/ f7 W滴水察海(69304838) 15:23:23
7 N: C: H c. u5 O" C! L8 a老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱% a6 O5 x8 j* f; B6 p
吉非替尼和S-1连用的依据& T# \) [8 k7 x/ I! c2 _; @6 V
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
, G. `5 ^ N) Y W! Y/ m: F是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
: M9 J$ a$ v0 z) L9 M4 W这样是不是推理出,耐药后,可以用S-1和培美了?
! w8 B- V( S% m5 Y; c结论:! d% }9 }4 j5 s) a2 A
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |