看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯，血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。& q1 B7 S# m3 h/ W% C# B
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: w9 r# l# ]1 _# E" I( E6 PCurrently available feasibility data for possible combination strategies. 2 T% L+ s9 t, G5 _) X5 Y
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Combination Feasibility according to preliminary data
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Bevacizumab + sorafenib Yes, reduced dose
9 ]/ v5 a- n2 a1 t( y9 a, i0 y RBevacizumab + sunitinib† No
( X- f2 A# ?9 s s; L; @Bevacizumab + temsirolimus Yes + O; o1 C* m( h4 }5 N# Z( B) N
Bevacizumab + everolimus Yes / h- @8 Q- Y# Y$ o
Sorafenib + sunitinib ? * w$ k9 b% T, m1 x4 e$ v9 K
Sorafenib + temsirolimus Yes, reduced dose
) F5 P/ F0 `$ s' K& ]Sorafenib + everolimus Yes, reduced dose " j, J3 h ^ i3 t, K
Sunitinib + temsirolimus† No
6 }: V, g* B- G( g) | ySunitinib + everolimus ? 3 g; X# L1 U- V. ?
Temsirolimus + everolimus ?
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†Led to US FDA warning.
" g2 C5 A% E \' a( [?: As yet unattempted combination.
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